Journal
BRITISH JOURNAL OF CANCER
Volume 88, Issue 8, Pages 1160-1167Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600885
Keywords
DMXAA; pharmacokinetics; pharmacodynamics; toxicity
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The purpose of this phase I, dose-escalation study was to determine the toxicity, maximum tolerated dose, pharmacokinetics, and pharmacodynamic end points of 5,6-dimethylxanthenone acetic acid (DMXAA). In all, 46 patients received a total of 247 infusions of DMXAA over 15 dose levels ranging from 6 to 4900 mg m(-2). The maximum tolerated dose was established at 3700 mg m(-2); dose-limiting toxicities in the form of urinary incontinence, visual disturbance, and anxiety were observed at the highest dose level (4900 mg m(-2)). The pharmacokinetics of DMXAA were dose dependent. Peak concentrations and area under the curve level increased from 4.8 mum and 3.2 mum h, respectively, at 6 mg m(-2) to 1290 mum and 7600 mum h at 3700 mg m(-2), while clearance declined from 7.4 to 1.71 h(-1) m(-2) over the same dose range. The terminal half-life was 8.1 +/- 4.3 h. More than 99% of the drug was protein bound at doses up to 320 mg m(-2); at higher doses the percent free drug increased to a maximum of 6.9% at 4900 mg m(-2). Dose-dependent increases in the serotonin metabolite 5-hydroxyindoleacetic acid were observed at dose levels of 650 mg m(-2) and above. There was one unconfirmed partial response at 1300 mg m(-2). In conclusion, DMXAA is a novel vascular targeting agent and is well tolerated. (C) 2003 Cancer Research UK.
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