Journal
NEUROLOGY
Volume 60, Issue 8, Pages 1388-1390Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000058768.73358.1A
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Funding
- NIAID NIH HHS [AI 30731, U01 AI027664, AI 27664, K23 AI001600-05, K23 AI001600, P01 AI030731] Funding Source: Medline
- NIMH NIH HHS [R21 MH063647, MH 63647] Funding Source: Medline
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The authors assessed CSF and plasma HIV-1 RNA and neuropsychological test performance (composite neuropsychological test Z score [NPZ-4]) in 25 HIV-1-infected subjects 4 and 8 weeks after beginning potent antiretroviral therapy that included a protease inhibitor. In the 14 subjects who entered the study on no antiretroviral treatment, NPZ-4 improvement was associated with decline in CSF HIV-1 RNA at both visits (p = 0.001 and p = 0.02), and those treated with zidovudine or indinavir had greater improvement in NPZ-4 at both visits compared to those treated with other drugs (p = 0.003 and p = 0.01).
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