Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 994, Issue 1-2, Pages 93-102Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(03)00318-2
Keywords
forensic analysis; monolithic columns; gradient elution; libraries; MS; opiates; Benzodiazepines; lysergic acid diethylamide; barbiturates
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A fast liquid chromatography-electrospray tandem mass spectrometric (LC-ESI-MS-MS) method by using a monolithic column, gradient elution and ion trap mass spectrometer was developed for 14 forensically interesting and chemically different compounds. All compounds were eluted within 2.5 min and the total analysis time was 5 min including stabilisation time required for the next injection. All the compounds, basics, neutrals and acids were efficiently ionised by positive ion ESI. A laboratory library including MS-MS spectra and retention times was developed and tested. Results with 476 standard samples and 50 authentic samples showed that the compounds studied can be unambiguously identified with the library. A quantitative method was developed for the compounds using external calibration. The evaluation process showed good linearity of the method and reasonable repeatability. Limits of detection ranged from 10.0 to 50.0 ng/ml. (C) 2003 Elsevier Science B.V. All rights reserved.
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