Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Volume 358, Issue 1432, Pages 649-655Publisher
ROYAL SOC LONDON
DOI: 10.1098/rstb.2002.1255
Keywords
long-term depression; metaplasticity; visual cortex; ocular dominance plasticity; Hebb; Bienenstock-Cooper-Munro (BCM) theory
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Theories of receptive field plasticity and information storage make specific assumptions for how synapses are modified. I give a personal account of how testing the validity of these assumptions eventually led to a detailed understanding of long-term depression and metaplasticity in hippocampal area CA1 and the visual cortex. The knowledge of these molecular mechanisms now promises to reveal when and how sensory experience modifies synapses in the cerebral cortex.
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