Journal
JOURNAL OF CONTROLLED RELEASE
Volume 89, Issue 2, Pages 321-328Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(03)00124-X
Keywords
transdermal delivery; 6-ketocholestanol; phloretin; sodium-fluorescein; confocal laser scanning microscopy
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In the present study. we investigated the feasibility of enhancing the transport of the model drug sodium-fluorescein across rat. porcine and human skin by treating it with phloretin and 6-ketocholestanol. Both 6-ketocholestanol and phloretin were incorporated into unilamellar liposomes and used as a skin pre-treatment. Afterwards standard diffusion experiments with Franz-type diffusion cells were performed. The results indicate a positive effect of 6-ketocholestanol on the sodium-fluorescein diffusion in all skin types, whereas phloretin had no significant influence compared to the control in human skin. In contrast to this. phloretin had a significant positive effect in rat as well as in porcine skin after 30 h of diffusion. In addition to the permeation studies, the human skin samples were analysed by confocal laser scanning microscopy for direct visualisation of the sodium-fluorescein. As expected the results of the diffusion experiments were confirmed by this microscopic method. (C) 2003 Elsevier Science B.V. All rights reserved.
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