Journal
JOURNAL OF INFECTION
Volume 46, Issue 4, Pages 215-220Publisher
W B SAUNDERS CO LTD
DOI: 10.1053/jinf.2002.1064
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Objectives: To study whether NRAMP1 gene polymorphisms in a Japanese population affect susceptibility to tuberculosis and clinical features of tuberculosis. Methods: Polymerase chain reaction and restriction fragment-length polymorphism analyses were used to type NRAMP1 polymorphisms in 95 patients with pulmonary tuberculosis and 90 controls. Clinical features of patients also were investigated. Results: No association was seen between susceptibility to tuberculosis and NRAMP1 polymorphisms. Patients with the D543N A allele were significantly more likely than others to develop a cavitary lesion; by logistic regression analysis with adjustment for gender, age, and presence of diabetes, the odds ratio in patients with an A allele was 5.16 (95% confidence interval, 1.30-20.45). Conclusions: Genetic variation in the human NRAMP1 gene may be associated with cavitation in patients with tuberculosis. (C) 2003 The British Infection Society. Published by Elsevier Science Ltd. All rights reserved.
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