Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 162, Issue 1, Pages 113-121Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1090-7807(02)00197-0
Keywords
T-1 rho; MRI; artifacts; beta(1); rotary echo
Funding
- NCRR NIH HHS [RR-02305] Funding Source: Medline
- NIAMS NIH HHS [R01-AR45242] Funding Source: Medline
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Significant artifacts arise in T-1rho-weighted imaging when nutation angles suffer small deviations from their expected values. These artifacts vary with spin-locking time and amplitude, severely limiting attempts to perform quantitative imaging or measurement of T-1rho relaxation times. A theoretical model explaining the origin of these artifacts is presented in the context of a T-1rho-prepared fast spin-echo imaging sequence. Experimentally obtained artifacts are compared to those predicted by theory and related to B-1 inhomogeneity. Finally, a self-compensating spin-locking preparatory pulse cluster is presented, in which the second half of the spin-locking pulse is phase-shifted by 180degrees. Use of this pulse sequence maintains relatively uniform signal intensity despite large variations in flip angle, greatly reducing artifacts in T-1rho-weighted imaging. (C) 2003 Elsevier Science (USA). All rights reserved.
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