Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 38, Issue 5, Pages 513-518Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(03)00074-6
Keywords
ibuprofen amides; analgesic activity; ulcerogenic activity; aminopyridine; aminopyrimidine
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A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect. (C) 2003 Editions scientificlues et medicales Elsevier SAS. All rights reserved.
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