Journal
JOURNAL OF BIOMECHANICS
Volume 36, Issue 5, Pages 721-730Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0021-9290(02)00450-5
Keywords
calcium; length-dependent activation; molecular motor; myofilament; sarcomere dynamics
Categories
Funding
- NHLBI NIH HHS [R01-HL63704, P01-HL62426, R01-HL52322] Funding Source: Medline
- PHS HHS [T32-07692] Funding Source: Medline
Ask authors/readers for more resources
The mechanical properties of the cardiac myofilament are an important determinant of pump function of the heart. This report is focused on the regulation of myofilament function in cardiac muscle. Calcium ions form the trigger that induces activation of the thin filament which, in turn, allows for cross-bridge formation, ATP hydrolysis, and force development. The structure and protein-protein interactions of the cardiac sarcomere that are responsible for these processes will be reviewed. The molecular mechanism that underlies myofilament activation is incompletely understood. Recent experimental approaches have been employed to unravel the mechanism and regulation of myofilament mechanics and energetics by activator calcium and sarcomere length, as well as contractile protein phosphorylation mediated by protein kinase A. Central to these studies is the question whether such factors impact on muscle function simply by altering thin filament activation state, or whether modulation of cross-bridge cycling also plays a part in the responses of muscle to these stimuli. (C) 2003 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available