Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 5, Pages 712-715Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030014t
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Funding
- NCI NIH HHS [1-U19-CA67775-07] Funding Source: Medline
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An examination of an organic extract of the cyanobacterium Lyngbya majuscula, collected from Wasini Island off the southern Kenyan coast, led to the isolation of the known cyclic depsipeptide antanapeptin A (1), recently isolated from a Madagascan collection of L. majuscula, and a new bioactive cyclic depsipeptide, homodolastatin 16 (2). The structures of these two compounds were determined from NMR and mass spectrometry data. Homodolastatin 16, a higher homologue of the potential anticancer agent dolastatin 16, exhibited moderate activity against oesophageal and cervical cancer cell lines.
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