Journal
JOURNAL OF IMMUNOLOGY
Volume 170, Issue 9, Pages 4593-4600Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.9.4593
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Funding
- NCI NIH HHS [CA14520] Funding Source: Medline
- NIAID NIH HHS [AI042990] Funding Source: Medline
- NIGMS NIH HHS [T32GM07215] Funding Source: Medline
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The TNFR family member BAFF-R facilitates peripheral B cell development, although it is unclear whether it promotes survival of B cells, or also initiates a differentiation program. We show that disruption of the BAFF-R encoding gene Tnfrsf13c in strain A/WySnJ mice causes a progressive decline in peripheral B cell numbers, beginning at the transitional 1 developmental stage and continuing through the mature peripheral B cell stage. Bcl-x(L) overexpression in A/WySnJ B cells decreased the turnover of transitional B cells, as determined by 5-bromo-2'-deoxyuridine labeling, and restored follicular B cell development. We conclude that the mutant A/WySnJ allele of Tnfrsf13c can be complemented through the survival signal provided by Bcl-x(L).
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