Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 49, Issue 5, Pages 968-971Publisher
WILEY
DOI: 10.1002/mrm.10417
Keywords
magnetic resonance imaging; cells; iron oxide; microimaging; cell labeling
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In the present work, we demonstrate that the steady-state free precession (SSFP) imaging pulse sequence FIESTA (fast imaging employing steady state acquisition) used in conjunction with a custom-built insertable gradient coil and customized RF coils can be used to detect individual SPIO-labeled cells using a commonly available 1.5 T clinical MRI scanner. This work provides the first evidence that single-cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans. (C) 2003 Wiley-Liss, Inc.
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