Journal
NEOPLASIA
Volume 5, Issue 3, Pages 218-228Publisher
NEOPLASIA PRESS
DOI: 10.1016/S1476-5586(03)80054-4
Keywords
epithelial cancers; transcriptional activation; chromosomal domains; expression profiling; microarray
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Funding
- NCI NIH HHS [1R01CA89827-01, R01 CA089827, R01 CA76173] Funding Source: Medline
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Despite remarkable advances in our understanding of a genetic basis of cancer, the precise molecular definition of the phenotypically relevant genetic features associated with human epithelial malignancies remains a significant and highly relevant challenge. Here we performed a systematic analysis of the chromosomal positions of cancer-associated transcripts for prostate, breast, ovarian, and colon tumors, and identified short segments of human chromosomes that appear to represent a common target for transcriptional activation in major epithelial malignancies in human. These cancer-associated transcriptomeres correspond well to the regions of transient transcriptional activity on chromosomes 1q21-q23 (144-160 Mbp), 12q13 (52-63 Mbp), 17q21 (38-50 Mbp), 17q23-q25 (72-82 Mbp), 19p13 (1-16 Mbp), and Xq28 (132-142 Mbp) during human cell cycle, suggesting a common epigenetic mechanism of transcriptional activation. Consistent with this idea, two of these transcriptomeres (12q13 and 17q21) seemed to be related to the p53-regulated transcriptional clusters, and some of the cancer-associated transcriptomeres appeared to correspond well to the recently identified regions of increased gene expression on human chromosomes.
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