Journal
SYNLETT
Volume -, Issue 6, Pages 847-848Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-38748
Keywords
palladium; cytotoxic activity; pyrroloquinazoline alkaloid
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Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aq AgNO3 gave luotonin B in good yield.
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