4.4 Article

A convenient synthesis of luotonins A and B

Journal

SYNLETT
Volume -, Issue 6, Pages 847-848

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-38748

Keywords

palladium; cytotoxic activity; pyrroloquinazoline alkaloid

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Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aq AgNO3 gave luotonin B in good yield.

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