Journal
MASS SPECTROMETRY REVIEWS
Volume 22, Issue 3, Pages 195-214Publisher
WILEY
DOI: 10.1002/mas.10050
Keywords
high-throughput analysis; biological fluids; quantitation; LC-MS
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To support pharmacokinetic and drug metabolism studies, LC-MS/MS plays more and more an essential role for the quantitation of drugs and their metabolites in biological matrices. With the new challenges encountered in drug discovery and drug development, new strategies are put in place to achieve high-throughput analysis, using serial and parallel approaches. To speed-up method development and validation, generic approaches with the direct injection of biological fluids is highly desirable. Column-switching, using various packing materials for the extraction columns, is widely applied. Improvement of mass spectrometers performance, and in particular triple quadrupoles, also strongly influences sample preparation strategies, which remain a key element in the bioanalytical process. (C) 2003 Wiley Periodicals, Inc.
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