Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 9, Issue 5, Pages 441-444Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1469-0691.2003.00571.x
Keywords
Cryptococcus neoformans; HIV negative; fluconazole resistance; meningitis; CLL
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Cases of fluconazole-resistant Cryptococcus neoformans have been reported in AIDS patients previously treated with fluconazole. We report a case of fluconazole-resistant cryptococcal meningitis in an HIV-negative patient not previously exposed to fluconazole. The patient experienced a clinical relapse after discontinuation of therapy with amphotericin B and subsequent initiation of fluconazole therapy. In vitro resistance was initially verified by Etest and tablet diffusion and later confirmed by NCCLS broth microdilution.
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