Journal
ORGANIC LETTERS
Volume 5, Issue 9, Pages 1523-1526Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol034314d
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- NCI NIH HHS [CA 34303] Funding Source: Medline
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[GRAPHICS] A halogen-selective tandem intramolecular Heck/carbonylation reaction has been developed for the construction of the C,E,F-ring system and the C20 quaternary center found in perophoramidine (1). This process can be effected in good yields in the presence of both the chlorine and bromine atoms found in the natural product. In addition, it is possible to introduce the quaternary center at N in a stereoselective manner by a lactone enolate alkylation, using NaH and allyl bromide.
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