Journal
SCHIZOPHRENIA RESEARCH
Volume 61, Issue 1, Pages 31-37Publisher
ELSEVIER
DOI: 10.1016/S0920-9964(02)00224-4
Keywords
schizophrenia; genetics; association; monoamine oxidase A (MAOA) gene
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Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n = 133) and control subjects (n = 377), In men, there was an association between the less efficiently transcribed alleles and schizophrenia (chi(2) =4.01, df=1, p < 0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated. (C) 2002 Elsevier Science B.V. All rights reserved.
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