Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 61, Issue 3, Pages 189-196Publisher
SPRINGER
DOI: 10.1007/s00253-002-1201-7
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This Mini-Review summarizes the current knowledge on the biochemical and physiological events leading to massive citric acid accumulation by Aspergillus niger under industrially comparable conditions, thereby particularly emphasizing the roles of glycolytic flux and its control, excretion of citric acid from the mitochondria and the cytosol, and the critical fermentation variables. The potential of novel techniques for metabolic analysis and genomic approaches in understanding this fermentation is also discussed.
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