2-octyl cyanoacrylate adhesive for conjunctival wound closure in rabbits

Purpose: To evaluate the efficacy and histology of 2-octyl cyanoacrylate in conjunctival wound closure in rabbits. Methods: Ten eyes of 10 New Zealand white rabbits were used. Eight rabbits had conjunctival wounds that were repaired with 2-octyl cyanoacrylate. Two rabbits were killed at 1 week and two rabbits were killed at 2 weeks and their conjunctivae were examined histologically. From two additional rabbits, conjunctival strips were obtained that underwent tensile strength testing. Results: All conjunctival wounds closed well with 2-octyl cyanoacrylate. Histology revealed minimal inflammation of the wounds. The tensile strength of conjunctival strips glued together was 25.5 g (standard deviation, 1.9 g). Conclusion: 2-Octyl cyanoacrylate may be a possible tissue adhesive for conjunctival wound closure.