Journal
JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS
Volume 40, Issue 3, Pages 152-155Publisher
SLACK INC
DOI: 10.3928/0191-3913-20030501-09
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- NEI NIH HHS [EY01792] Funding Source: Medline
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Purpose: To evaluate the efficacy and histology of 2-octyl cyanoacrylate in conjunctival wound closure in rabbits. Methods: Ten eyes of 10 New Zealand white rabbits were used. Eight rabbits had conjunctival wounds that were repaired with 2-octyl cyanoacrylate. Two rabbits were killed at 1 week and two rabbits were killed at 2 weeks and their conjunctivae were examined histologically. From two additional rabbits, conjunctival strips were obtained that underwent tensile strength testing. Results: All conjunctival wounds closed well with 2-octyl cyanoacrylate. Histology revealed minimal inflammation of the wounds. The tensile strength of conjunctival strips glued together was 25.5 g (standard deviation, 1.9 g). Conclusion: 2-Octyl cyanoacrylate may be a possible tissue adhesive for conjunctival wound closure.
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