Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 5, Pages 667-670Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np020544+
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Funding
- NCI NIH HHS [CA-49084, CA-67775] Funding Source: Medline
- NIGMS NIH HHS [GM 56553] Funding Source: Medline
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Five novel brominated polyacetylenic diols, diplynes A-E (2-6), and three sulfated analogues, diplyne A 1-sulfate (7), diplyne C 1-sulfate (8), and 2-deoxydiplyne D sulfate (9), were isolated from the Philippines sponge Diplastrella sp. by employing bioassay-guided fractionation using the HIV-1 integrase inhibition assay. The novel metabolites were characterized by interpretation of spectroscopic data.
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