Journal
BIOLOGY OF THE CELL
Volume 95, Issue 3-4, Pages 157-167Publisher
WILEY
DOI: 10.1016/S0248-4900(03)00032-7
Keywords
ATPase; Saccharomyces cerevisiae; cell free translation; eIF4A Ded1p
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RNA helicases of the DEAD-box and related families have been found to be required for all processes involving RNA molecules. Biochemical and genetic analyses have shown that at least two RNA helicases are required for translation initiation in yeast. Although it is generally, believed that these enzymes are necessary to unwind secondary structures in the 5' untranslated region of mRNAs, their exact role has not been convincingly shown. We discuss here our present knowledge of the function of eIF4A and Ded1p, two DEAD-box proteins required for translation in eukaryotic cells. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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