Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 160, Issue 5, Pages 996-998Publisher
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajp.160.5.996
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Objective: This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. Method: Thirty-six depressed patients were randomly assigned to receive DHA, 2 g/day, or placebo for 6 weeks. Response was defined a priori as a greater than or equal to50% reduction in the score on the Montgomery-Asberg Depression Rating Scale. Thirty-five participants were evaluable; 18 received DHA, and 17 received placebo. Results: Response rates were 27.8% in the DHA group and 23.5% in the placebo group. The difference in response rates between groups did not reach statistical significance. Conclusions: This trial failed to show a significant effect of DHA monotherapy in subjects with major depression.
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