Journal
APPLIED SPECTROSCOPY
Volume 57, Issue 5, Pages 522-525Publisher
SOC APPLIED SPECTROSCOPY
DOI: 10.1366/000370203321666533
Keywords
Raman; near infrared; urine; spectroscopy; creatinine; hybrid linear analysis; HLA
Categories
Ask authors/readers for more resources
Spectroscopic methods of urinalysis offer several advantages over chemical methods, including less sample contact and higher information content. In particular, urine creatinine has been the subject of several spectroscopic studies. We report the first use of Raman spectroscopy to measure creatinine concentrations in unaltered urine samples from a multipatient population. Using near-infrared excitation and a hybrid linear analysis calibration method, a root mean squared error of cross-validation (RMSECV) of 4.9 mg/dL was obtained. The error in the reference chemical method was 1.1 mg/dL. This result shows that the Raman spectroscopy can measure creatinine at clinical levels even in the presence of patient-to-patient variations. Because most assays in urine require creatinine concentration in order to correct for fluctuations in water content, measurement of creatinine is the first step towards more extensive Raman-based urinalysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available