Journal
TRENDS IN CELL BIOLOGY
Volume 13, Issue 5, Pages 270-277Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(03)00077-1
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Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future.
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