Journal
TRAFFIC
Volume 4, Issue 5, Pages 291-301Publisher
WILEY
DOI: 10.1034/j.1600-0854.2003.00086_4_5.x
Keywords
APP; endocytosis; gene transcription; lipoprotein receptor; LRP; neurodevelopment; protein kinase; Reelin; signal transduction; Wnt
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Funding
- NHLBI NIH HHS [R37 HL063762] Funding Source: Medline
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Low-density lipoprotein receptor-related proteins (LRPs) are evolutionarily ancient cell-surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family. Here, we will summarize recent advances in our understanding of the molecular basis on which these receptors function during development .
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