Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 8, Issue -, Pages D855-D869Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1097
Keywords
BMP; embryogenesis; patterning; gastrulation; receptor; kinase; skeletalgenesis; review
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Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.
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