Journal
CELL CALCIUM
Volume 33, Issue 5-6, Pages 519-531Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/S0143-4160(03)00057-5
Keywords
TRPM channels; multimers; enzymes; oxidant stress; ADP-ribose; NUDT9
Categories
Funding
- PHS HHS [R01 64091] Funding Source: Medline
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TRPM2 is a recently identified TRPM family cation channel which is unique among known ion channels in that it contains a C-terminal domain which is homologous to the NUDT9 ADP-ribose hydrolase and possesses intrinsic ADP-ribose hydrolase activity. Here, available information on the TRPM2 gene, transcripts, predicted protein products, and assembled multimeric channels is comprehensively reviewed and synthesized to highlight important areas for future work and provide insight into potential biological function(s) of TRPM2 channels. (C) 2003 Elsevier Science Ltd. All rights reserved.
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