Journal
BIOLOGICAL CHEMISTRY
Volume 384, Issue 5, Pages 737-747Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2003.082
Keywords
gene delivery; gene vectors; magnetic drug targeting; magnetic nanoparticles; magnetofection
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In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical limitations to gene delivery. Magnetic particle chemistry and physics are discussed, followed by a detailed presentation of vector formulation and optimization work. While magnetofection does not necessarily improve the overall performance of any given standard gene transfer method in vitro, its major potential lies in the extraordinarily rapid and efficient transfection at low vector doses and the possibility of remotely controlled vector targeting in vivo.
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