Journal
BASIC RESEARCH IN CARDIOLOGY
Volume 98, Issue 3, Pages 149-157Publisher
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s00395-003-0406-y
Keywords
brain; kidney; mesentery; myocardial infarction; myocardial ischemia; preconditioning at a distance; remote preconditioning; signal transduction
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Conventional ischemic preconditioning is the phenomenon whereby brief episodes of myocardial ischemia render the ischemic territory resistant to a subsequent, sustained ischemic insult. A growing body of evidence further indicates that brief ischemia applied in distant organs and tissues can also protect naive, virgin myocardium from ischemic injury. In this review, we describe the initial observations that provided the impetus for the study of 'remote preconditioning', and summarize our current knowledge of the three facets of 'preconditioning at a distance'-intra-cardiac, inter-organ and transferred inter-cardiac preconditioning.
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