Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 38, Issue 5, Pages 533-536Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(03)00061-8
Keywords
iodobenzenediacetate; brigeheadtriazoles; triazolopyridines; triazoloquinolines; antibacterial activity
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Oxidation of 2-pyridyl and 2-quinylhydrazones with iodobenzene diacetate (IBD) in dichloromethane yield 1-aryl/hetryl-1,2,4-trizolo-[4,3-a] pyridines (3a-f) and 1-aryl/hetryl-5-methyl-1,2,4-triazolo[4,3-a] quinolines (6a-f). Seven compounds were tested in vitro for their antibacterial activity. 1-(5'-Nitro-2-furyl)-5-methyl-1,2,4-triazolo[4,3-a]quinoline (6e) was associated with substantially higher antibacterial activity than some commercial antibiotics against Salmonella typhi at MIC i.e. 10 mug mL(-1). (C) 2003 Published by Editions scientifiques et medicales Elsevier SAS.
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