Journal
ARTHRITIS AND RHEUMATISM
Volume 65, Issue 4, Pages 1097-1106Publisher
WILEY-BLACKWELL
DOI: 10.1002/art.37850
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Funding
- Autoimmunity Centers of Excellence
- National Institute of Allergy and Infectious Diseases, NIH [U19-AI-056363]
- Genentech, Inc.
- Pennsylvania Department of Health
- Genentech
- Biogen Idec
- Amplimmune
- Daiichi-Sankyo
- Takeda
- Novartis
- Amgen
- URL Pharma
- National Institutes of Allergy and Infectious Diseases (NIAID)
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Objective To study the safety and clinical efficacy of rituximab therapy for primary Sjogren's syndrome, as well as to investigate its mechanisms. Methods Patients with primary Sjogren's syndrome were enrolled in an open-label trial, were given rituximab (1 gm) infusions on days 1 and 15, and were monitored through week 52. The primary end point was safety, with secondary end points evaluating clinical and biologic efficacy. Blood was obtained for enumeration of lymphocyte subsets, measurement of serum autoantibody and BAFF levels, and analysis of gene expression. Results Twelve female patients with primary Sjogren's syndrome were administered rituximab. They had a median age of 51 years (range 3469 years) and a median disease duration of 8.0 years (range 218 years). We observed no unexpected toxicities from the rituximab therapy. Modest improvements were observed at week 26 in patient-reported symptoms of fatigue and oral dryness, with no significant improvement in the objective measures of lacrimal and salivary gland function. The recovery of blood B cells following the nadir from rituximab therapy was characterized by a predominance of transitional B cells and a lack of memory B cells. While blood B cell depletion was associated with an increase in serum BAFF levels, no significant changes were observed in the levels of serum anti-Ro/SSA, anti-La/SSB, and antitype 3 muscarinic acetylcholine receptor autoantibodies or in the blood interferon signature. Conclusion In patients with primary Sjogren's syndrome, a single treatment course of rituximab was not associated with any unexpected toxicities and led to only modest clinical benefits despite effective depletion of blood B cells.
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