Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 121, Issue 3, Pages 458-461Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04305.x
Keywords
B-CLL; monoclonal antibodies; internalization
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B-cell chronic lymphocytic leukaemia (B-CLL) cannot be cured by conventional chemotherapy, therefore, toxin-linked therapeutic monoclonal antibodies (mAbs) are increasingly examined for their potential to improve clinical outcome. The current study aimed to identify mAbs that were internalized by the B-CLL cells of 14 patients, using both flow cytometry and confocal laser scanning microscopy. Anti-CD5, CD22 and CD40 mAbs were effectively taken up by B-CLL cells, whereas mAbs against CD19, CD20, CD23 and CD45 were not. This study may form a basis for further research to identify antibodies that may serve as carriers for toxins to treat B-CLL.
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