Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 4, Issue 5, Pages 397-407Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1103
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The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.
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