Journal
MICROBES AND INFECTION
Volume 5, Issue 6, Pages 515-526Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(03)00068-6
Keywords
adenosine; receptor; sepsis; infectious disease
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Adenosine can be described as a retaliatory metabolite, the production and release of which is usually enhanced under adverse environmental conditions. Binding via specific receptors, adenosine activates endogenous protective mechanisms aiming at the restoration of tissue homeostasis. While adenosinergic downregulation of tissue damage is beneficial in acute inflammation, chronic suppression of the immune system by adenosine may account for immunoparalysis in long-term septic patients. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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