Journal
KIDNEY INTERNATIONAL
Volume 63, Issue -, Pages S69-S71Publisher
ELSEVIER SCIENCE INC
DOI: 10.1046/j.1523-1755.63.s84.40.x
Keywords
sepsis; septic shock; cytokines; endotoxin; LPS; hemofiltration; plasmapheresis; adsorption; multiorgan failure; plasma filtration
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Sepsis remains the major cause of mortality worldwide, claiming millions of lives each year. The past decade has seen major advances in the understanding of the biological mechanisms involved in this complex process. Unfortunately, no definitive therapy yet exists that can successfully treat sepsis and its complications. In this review, we will address the significance of circulating cytokines in the pathophysiology of sepsis and its relevance to new approaches in extracorporeal therapies.
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