Journal
NATURE NEUROSCIENCE
Volume 6, Issue 5, Pages 519-525Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1039
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Funding
- NHLBI NIH HHS [HL07312-22] Funding Source: Medline
- NIDCD NIH HHS [DC04156] Funding Source: Medline
- NIGMS NIH HHS [T32 GMO7270] Funding Source: Medline
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It is commonly assumed that odorants are detected by the main olfactory epithelium (MOE) and pheromones are sensed through the vomeronasal organ (VNO). The complete loss of MOE-mediated olfaction in type-3 adenylyl cyclase knockout mice (AC3(-/-)) allowed us to examine chemosensory functions of the VNO in the absence of signaling through the MOE. Here we report that AC3(-/-) mice are able to detect certain volatile odorants via the VNO. These same odorants elicited electro-olfactogram transients in the VNO and MOE of wild-type mice, but only VNO responses in AC3(-/-) mice. This indicates that some odorants are detected through an AC3-independent pathway in the VNO.
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