Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 89, Issue 1, Pages 48-55Publisher
WILEY
DOI: 10.1002/jcb.10480
Keywords
mobile phone radiation; hsp70; heat shock protein; HSP70 promoter; DNA; electron transfer; MAPK cascades
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In this report we examined the effects of a discontinuous radio frequency (RF) signal produced by a GSM multiband mobile phone (900/1,900 MHz; SARsimilar to1.4 W/kg) on Drosophila melanogaster, during the 10-day developmental period from egg laying through pupation. As found earlier with low frequency exposures, the non-thermal radiation from the GSM mobile phone increased numbers of offspring, elevated hsp70 levels, increased serum response element (SRE) DNA-binding and induced the phosphorylation of the nuclear transcription factor, ELK-1. The rapid induction of hsp70 within minutes, by a non-thermal stress, together with identified components of signal transduction pathways, provide sensitive and reliable biomarkers that could serve as the basis for realistic mobile phone safety guidelines. (C) 2003 Wiley-Liss, Inc.
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