4.8 Article

Direct catalytic asymmetric aldol-type reaction of aldehydes with ethyl diazoacetate

Journal

ORGANIC LETTERS
Volume 5, Issue 9, Pages 1527-1530

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0343257

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[GRAPHICS] The direct aldol-type condensation of aldehydes with ethyl diazoacetate catalyzed by the chiral complex of BINOL derivatives-Zr((OBu)-Bu-t)(4) gave beta-hydroxy alpha-diazo carbonyl compounds with moderate enantioselectivities (53-87% ee).

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