Journal
MATERIALS LETTERS
Volume 57, Issue 18, Pages 2623-2628Publisher
ELSEVIER
DOI: 10.1016/S0167-577X(02)01339-3
Keywords
tissue engineering; solid freeform fabrication; scaffold; multi-nozzle deposition manufacturing
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The fabrication technology of Multi-nozzle Deposition Manufacturing (MDM) was proposed to fabricate porous tissue engineering scaffolds. This digital forming technology was developed based on the layer-by-layer manufacturing principle of Solid Freeform Fabrication (SFF). A four-nozzle MDM system was designed to carry out MDM processes. Bone tissue engineering scaffolds with different properties were fabricated by single-nozzle deposition process, bi-nozzle deposition process and tri-nozzle deposition process, respectively, in the MDM system. The bone scaffolds made by the single-nozzle deposition process in the MDM system have good biocompatibility and bone conductive property as a molecular scaffold for bone morphogenic protein (BNIP) in the implantation experiment of repairing segment defect of rabbit radius. (C) 2002 Elsevier Science B.V. All rights reserved.
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