Journal
PEDIATRIC NEUROLOGY
Volume 28, Issue 5, Pages 382-384Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0887-8994(03)00005-5
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A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy. Computed tomography revealed cerebral atrophy, and electroencephalography presented slow background activity. Consciousness cleared only 12 hours after valproic acid was discontinued, and normal electroencephalography results were evident 1 week later. Cerebral atrophy was nonexistent 2 months later. This rapidly developing but reversible alteration of consciousness in parallel with brain atrophy is recognized as a rare idiosyncratic adverse effect of valproic acid. (C) 2003 by Elsevier Inc. All rights reserved.
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