4.7 Article

Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins

Journal

ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 376, Issue 1, Pages 134-137

Publisher

SPRINGER-VERLAG BERLIN
DOI: 10.1007/s00216-003-1850-0

Keywords

capillary electrophoresis; sulfated cyclodextrins; cocaine stereoisomers; (-)-cocaine HCl; (+)-cocaine base; (-)-pseudococaine; (+)- pseudococaine

Funding

  1. NIDA NIH HHS [DA 12043] Funding Source: Medline

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A capillary electrophoretic method for the separation of cocaine and its stereoisomers was developed. In this study, the effect of organic modifier was also investigated. The separation was achieved using 1% sulfated cyclodextrin, 10 mmol L-1 phosphate buffer, 10% methanol at pH 3. The method provides good reproducibility and easy application.

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