Anti-HIV agents.: Part 55:: 3′R,4′R-di-(O)-(-)-camphanoyl-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent

3'R,4'R-Di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) (2) was designed and synthesized on the basis of a structure-activity relationship study of 3'R,4'R-di-O-(-)-camphanoyl-(+)-cis-khellactone DCK (1) and its analogues. DCP (2), a pyranochromone, and DCK (1), a pyranocoumarin, have different skeletons. Compound 2 showed potent in vitro inhibition of HIV-1 replication in H9 lymphocyte cells with an EC50 of 6.78 x 10(-4) muM and TI of 14,500. These values are comparable with those for DCK (1) and better than those of AZT in the same assay. (C) 2003 Elsevier Science Ltd. All rights reserved.