4.7 Article

Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens

Journal

JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 10, Pages 1795-1798

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jm025580k

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A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens. Promising in vitro antibacterial activity was demonstrated for compounds bearing this structural motif.

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