Journal
JOURNAL OF PHYSICAL CHEMISTRY A
Volume 107, Issue 18, Pages 3443-3449Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp022040q
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Funding
- NCRR NIH HHS [P41 RR008119] Funding Source: Medline
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We examined the effects of metallic silver colloids on the fluorescence spectral properties of indocyanine green (ICG), which is a dye widely used for in vivo medical testing. Silver colloids from a suspension bind spontaneously to amine-coated surfaces. These colloid-coated surfaces were found to cause a 30-fold increase in the intensity of ICG, which was held close to the metal surface by adsorbed albumin. The increased intensities of ICG were also associated with decreased lifetimes and increased photostability, which are indicative of modifying the fluorophores radiative decay rate. These results suggest the use of metal colloid-enhanced lCG for applications to retinal angiography and vascular imaging and as a contrast agent for optical tomography.
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