Journal
FEBS LETTERS
Volume 542, Issue 1-3, Pages 7-11Publisher
WILEY
DOI: 10.1016/S0014-5793(03)00333-8
Keywords
cytoskeleton; rho GTPase; calcium; calmodulin; cytokinesis
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A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell-cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross-talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E-cadherin and beta-catenin function and organizing microtubules. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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