Journal
JOURNAL OF CELL BIOLOGY
Volume 161, Issue 3, Pages 471-476Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200301125
Keywords
gene expression; induction; lac operon; computational modeling; regulation
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We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.
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