Journal
TETRAHEDRON LETTERS
Volume 44, Issue 20, Pages 3893-3895Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00829-3
Keywords
lipophilic gadolinium complexes; contrast agents; MRI; mixed micelles; cholesterol
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A straightforward and efficient synthesis of Gd-DTPA-cholesterol is reported. This new lipophilic gadolinium complex can be easily incorporated into mixed micelles in order to achieve MRI contrast agents with increased relaxivity. These supramolecular systems can find potential application in magnetic resonance angiography (MRA). (C) 2003 Elsevier Science Ltd. All rights reserved.
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