Interactions of amphiphilic calix[4]arene-based Solid Lipid Nanoparticles with bovine serum albumin

The interaction of Solid Lipid Nanoparticles (SLN) based on amphiphilic calix[4]arene with one of the major circulatory protein, serum albumin, has been investigated by Photon Correlation Spectroscopy (PCS) and Atomic Force Microscopy (AFM). The carrier systems have shown the ability to interact with bovine serum albumin (BSA), which forms a capping layer up to 17 nm in depth. AFM imaging revealed that the SLNs are protected by this layer against flattening on surfaces. (C) 2003 Elsevier Science B.V. All rights reserved.