Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 1, Issue 11, Pages 1833-1834Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b303113f
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The enantioselective synthesis of a potent Maxi-K potassium channel opener (BMS-204352) mediated by N-fluoroammonium salts of cinchona alkaloids is described. Two synthetic pathways were evaluated. An ee as high as 88% was achieved (> 99% after a single recrystallisation).
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